Journal: Frontiers in Bioengineering and Biotechnology
Article Title: Signatures of disease progression in knee osteoarthritis: insights from an integrated multi-scale modeling approach, a proof of concept
doi: 10.3389/fbioe.2023.1214693
Figure Lengend Snippet: Workflow of the study: (A–C) represent the MSK modeling pipeline to estimate subject-specific knee joint kinematics and kinetics (D,E) represent the FE modeling pipeline to estimate cartilage tissue responses. Red arrows indicate unique approaches: consistent knee geometries in MS and FE pipelines, and MSK-workflow derived subject-specific loading and boundary conditions as inputs for FE model.
Article Snippet: The state-of-the-art OpenSim-JAM workflow uses standard OpenSim tools ( ) in combination with a unique knee joint contact model capable of estimating joint secondary coordinates (Anterior-posterior and medial-lateral translations, internal-external and adduction-abduction rotation).
Techniques: Derivative Assay